Endocrine Abstracts

Introduction: Phosphoenolpyruvate carboxykinase (PEPCK) is the key rate determining enzymes of gluconeogenesis pathway. PEPCK exists in cytosolic (PEPCK-C) and mitochondrial (PEPCK-M) isoforms. PEPCK isoforms maintain glucose/lipid homeostasis and is being explored as a therapeutic target for treating metabolic diseases. We tested the influence of a naturally occurring compound Genistein (a soy derived isoflavone) to constitutively regulate PEPCK isoforms to address its potent...